Origin of the High Molecular Weight Activator of Prekallikrein

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چکیده

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Origin of the high molecular weight activator of prekallikrein.

Two lines of evidence suggest that the high molecular weight activator of prekallikrein (large activator) (BAGDASARIAN, A., TALAMO, R. C., AND COLMAN, R. W. (1973) J. Biol. Chem. 248, 3456-3463) is derived from coagulation factor XII (Hageman factor). Large activator could not be isolated from plasma congenitally deficient in factor XII, and partial immunologic identity was demonstrated between...

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A Prealbumin Activator of Prekallikrein

Activation of a plasma fraction containing unactivated Hageman factor and prekallikrein followed by chromatography of this fraction on DEAE-cellulose revealed four peaks having bradykinin-generating activity. Peak 1 contained kallikrein; peaks 2-3, 4, and 5 each contained prekallikrein-activating activity. Elution of peaks 2-3, 4, and 5 from disc gels after electrophoresis at pH 9.3 revealed pe...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1973

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(19)43251-1